Clinical Trial Information
Optimice-Pcr: De-Escalation of Therapy in Early-Stage Tnbc Patients Who Achieve Pcr After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy- Category: Breast
- Status: Active
- Starts: Jul 14, 2023
- Trial Number: A012103
Principal Investigator: Jose Galeas, MD
Research Nurse: Wendy Blount, RN, MSN
Description of Trial:
NCT05812807
Optimice-Pcr: De-Escalation of Therapy in Early-Stage Tnbc Patients Who Achieve Pcr After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation will result in the same risk of cancer coming back as pembrolizumab after surgery in triple-negative breast cancer patients who achieve pathologic complete response after preoperative chemotherapy with pembrolizumab.
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